Endocrine Abstracts

Background: Insulin resistance (IR) is the common denominator of three multigenic disorders: type 2 diabetes mellitus, obesity, and PCOS. IR can result from genetic abnormalities involving proteins of the insulin signalling pathway, including PC-1 and IRS-1. The IRS-1 G972R variant had the highest world frequency and correlated with IR in PCOS Sicilian women (Horm Metab Res, 2010).Objective and methods: To determine: i) the rates of the G972R IRS-...

Background: PPI are known to diminish the intestinal absorption of L-T4, which is commonly ingested as tablets of L-T4 sodium salt. However, a liquid formulation is available (Tirosint, oral solution, IBSA Farmaceutici Italia s.r.l., Italy), in which the hormone is solubilized in 28.8% ethyl alcohol. One ml of this formulation (=28 drops) contains 100 mcg L-T4 sodium salt in 243 mg ethanol. Because this formulation contains L...